We are all looking to succeed in life, but rarely do we look at how to increase our capacity. Neither at home nor in school have we learned how to deal with stress, manage our emotions, or tap into our full potential.
During this free mini-workshop, we will experience a short glimpse of that potential through the practice of powerful breathing exercises and guided meditation. We will also learn some practical knowledge that helps transform this untapped energy source into success in our career. You will leave with powerful take-home techniques and ideas as well as an invitation to a world-renowned course in stress-relief through the breath.
The most game-changing thing I have done in my life. I feel like a new person. I'm calmer, more centered and more present in all situations. I meditate regularly but doing Sudarshan Kriya further helps to go in to the deep relaxing stage. A great place to find some much-needed solace and peace in our fast moving lives. The instructors are very caring and they take personal interest in each person.
Highly recommended. Greater clarity and focus, practical pointers and the ability to "re-charge on the spot" are just some of the very few lifelong lessons that I took away from it.
Learning the breathing techniques, the knowledge, meeting loving, smiling people I cannot even imagine my life without these! Eternally thankful! National Website Menu. Time: 11, 12, Fee: Cijena: 1. Course Id: A See other course dates and locations. Experiences of Happiness Program Participants.The European anchovy, Engraulis encrasicolusis currently one of the principal target species for commercial fisheries in Europe.
In both populations, the two markers revealed the presence of two main haplogroups, A and B, already detected in previous investigations of different classes of molecular markers.
The COI sequence analysis identified a non-synonymous transversion T to G at position of the translated sequence, resulting in an amino acid change. All COI sequences of haplogroup A had an amino acid sequence with alanine in this position, while serine was present in the same position in haplogroup B. The selection tests applied to the COI dataset revealed that codon was not under positive selection, that seven amino acid changes were under purifying selection, and that two amino acids were under episodic positive selection.
The European anchovy, Engraulis encrasicolus Linnaeus,is a clupeoid pelagic species widely distributed in the Mediterranean, Black and Azov Seas, Eastern Atlantic coastline from Norway to Angola [ 12 ], and around the tip of southern Africa [ 34 ]. Its biology has received particular attention due to the commercial interest of its fisheries [ 5 — 8 ].
In the last twenty years a number of scientific studies have focused on the detection of genetic population structure in this commercially important species, through morphological and molecular analyses. Molecular studies described a complex genetic structure of E. In the Atlantic Ocean and the Mediterranean Basin, ten genetically differentiated European anchovy populations have been identified by surveys of the variability of the mitochondrial control region with implications for the management of fishery stocks [ 1516 ].
The distribution of these haplogroups differs among natural populations but shows a constant proportion in each population, over time [ 1517 — 19 ].
Clade B prevails at the northern and southern high latitudes with frequencies decreasing towards the tropics, whereas clade A is present with higher frequencies in the tropical and subtropical areas [ 19 ]. Studies by Magoulas et al. It has also been suggested that the two mtDNA clades can also occur in simpatry, and that temperature seems to have shaped their relative frequency, as a result of range expansion and post-glacial secondary mixing [ 1819 ].
European anchovy population dynamics and distribution patterns are known to be strongly dependent on the environment. Thus, this species has been considered an ideal organism to study both the adaptative behaviour of small pelagic fish under different environmental conditions [ 19 ], and to understand the effect of quaternary climatic fluctuations on the distribution of marine organisms [ 14 ].
More specifically, studies by Silva et al. Further, Silva et al. Moreover, the main water masses present in this channel, connecting the western and the eastern basins of the Mediterranean Sea, are characterized by a complex multi-scale thermohaline circulation, driven by ocean currents, wind effects, and mesoscale activity.
All these environmental features are known to modify the temperature regime of the surface waters in the Sicilian anchovy habitat [ 2122 ]. Although the Sicilian Channel can be considered a key zone in the Mediterranean basin for the European anchovy population structure, few genetic studies [ 23 ] have been carried out in this area that was identified by Garcia Lafuente et al.
Based on the considerations above, in this study the genetic structure of four populations of European anchovy from the Tyrrhenian, Ionian and Adriatic seas and the Sicilian Channel was investigated through the sequence analysis of two mitochondrial markers already used to detect A and B haplogroups in E. The CR has been often used to infer intraspecific genetic structure and population demographic history [ 26 — 32 ].
Partial sequences of the mitochondrial Cytochrome c Oxidase I COI gene, a highly conserved, bioenergetic gene encoding for protein subunits of the respiratory chain [ 33 ], have been used to investigate the phylogeny of several animal taxa, including fishes, and as barcode sequences [ 34 — 39 ].
The aims are: i to explore the nucleotide sequences of the two mitochondrial markers to unveil the molecular traits discriminating the two haplogroups of E.
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A total of 74 adult individuals of morphologically identified E. Fishes were obtained from artisanal fish landing sites, at night.Data The benchmark data and the predictions are available on FigShare Note that according to CAFA rules, all but the top-ten methods are anonymized. However, methods are uniquely identified by a code number, so use of the data for further analysis is possible.
A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction.
However, assessing methods for protein function prediction and tracking progress in the field remain challenging.
We conducted the second critical assessment of functional annotation CAFAa timed challenge to assess computational methods that automatically assign protein function. We evaluated methods from 56 research groups for their ability to predict biological functions using Gene Ontology and gene-disease associations using Human Phenotype Ontology on a set of proteins from 18 species.
This increased accuracy can be attributed to a combination of the growing number of experimental annotations and improved methods for function prediction.
The assessment also revealed that the definition of top-performing algorithms is ontology specific, that different performance metrics can be used to probe the nature of accurate predictions, and the relative diversity of predictions in the biological process and human phenotype ontologies.
While there was methodological improvement between CAFA1 and CAFA2, the interpretation of results and usefulness of individual methods remain context-dependent. The online version of this article doi Accurate computer-generated functional annotations of biological macromolecules allow biologists to rapidly generate testable hypotheses about the roles that newly identified proteins play in processes or pathways.
They also allow them to reason about new species based on the observed functional repertoire associated with their genes. However, protein function prediction is an open research problem and it is not yet clear which tools are best for predicting function. At the same time, critically evaluating these tools and understanding the landscape of the function prediction field is a challenging task that extends beyond the capabilities of a single lab.
Assessments and challenges have a successful history of driving the development of new methods in the life sciences by independently assessing performance and providing discussion forums for the researchers [ 1 ]. In —, we organized the first critical assessment of functional annotation CAFA challenge to evaluate methods for the automated annotation of protein function and to assess the progress in method development in the first decade of the s [ 2 ].
The challenge used a time-delayed evaluation of predictions for a large set of target proteins without any experimental functional annotation.
A subset of these target proteins accumulated experimental annotations after the predictions were submitted and was used to estimate the performance accuracy. The estimated performance was subsequently used to draw conclusions about the status of the field.
In addition to validating investment in the development of new methods, CAFA1 also showed that using machine learning to integrate multiple sequence hits and multiple data types tends to perform well. However, CAFA1 also identified challenges for experimentalists, biocurators, and computational biologists.
These challenges include the choice of experimental techniques and proteins in functional studies and curation, the structure and status of biomedical ontologies, the lack of comprehensive systems data that are necessary for accurate prediction of complex biological concepts, as well as limitations of evaluation metrics [ 24 — 7 ]. Overall, by establishing the state-of-the-art in the field and identifying challenges, CAFA1 set the stage for quantifying progress in the field of protein function prediction over time.
In this study, we report on the major outcomes of the second CAFA experiment, CAFA2, that was organized and conducted in —, exactly 3 years after the original experiment. We were motivated to evaluate the progress in method development for function prediction as well as to expand the experiment to new ontologies. The CAFA2 experiment also greatly expanded the performance analysis to new types of evaluation and included new performance metrics.
By surveying the state of the field, we aim to help all direct and indirect users of computational function prediction software develop intuition for the quality, robustness, and reliability of these predictions.
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The time line for the second CAFA experiment followed that of the first experiment and is illustrated in Fig. Briefly, CAFA2 was announced in July and officially started in Septemberwhentarget sequences from 27 species were made available to the community. Teams were required to submit prediction scores within the 0,1] range for each protein—term pair they chose to predict on.
The submission deadline for depositing these predictions was set for January time point t 0. We then waited until September time point t 1 for new experimental annotations to accumulate on the target proteins and assessed the performance of the prediction methods. We will refer to the set of all experimentally annotated proteins available at t 0 as the training set and to a subset of target proteins that accumulated experimental annotations during t 0t 1 ] and used for evaluation as the benchmark set.
It is important to note that the benchmark proteins and the resulting analysis vary based on the selection of time point t 1.Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children.
He co-authored the only three books on pediatric gastrointestinal motility, and has published more than peer-reviewed original articles and 80 chapters, invited reviews and editorials. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:.
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Languages Spoken English French Italian. Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr.How to deal with doubts? - Sri Sri Ravi Shankar
Am J Gastroenterol. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. Di Lorenzo C. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials.
Neurogastroenterol Motil. J Pediatr. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Paediatr Drugs. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction.
Alioto A, Di Lorenzo C. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Pediatr Gastroenterol Hepatol Nutr. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation.
BMJ Open. Pediatr Radiol. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. Recommendations for pharmacological clinical trials in children with irritable bowel syndrome: the Rome foundation pediatric subcommittee on clinical trials. The rising cost of hospital care for children with gastroparesis: The project specifically refers to sex offenders and psychiatric operators within the prison.
Some members of the team took part to the project, attending the intensive course for Operators at the CIPM head quarter, so that Prison SMART became officially part of the rehab therapy used by the medical staff of the Treatment Unity.
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The results were presented by Conference speaker Dr. The most noticeable result was the increasing level of integration between sexual offenders taking part to the Project and common convicts. He believes that jail time should not be a punishment, but a chance for rehabilitation; he strongly believes that jail should become a place to grow, to take responsibility and finally, to heal.
As far as my experience is concerned, the general tendency of the convicts is to take distances from the crime they have committed. Denial is a chance. Sometimes they blame the guilt on someone else, even on the victim. In order to simplify I will share the evidence of a female convict arrested for killing her father in front of her mother.
She also admitted that she still loved her father, even if the homicide was due to a series of abuses she had suffered. The mood of mutual acceptance gradually arising during the course give participants the chance to get in touch with their crime, sometimes up to the point of taking responsibility for it.
It is a fact that in most Italian prisons, sex offenders are marginalized by other inmates.
I do not know what happened during the meditations in that course, I only know that by the end of the course, they were looking each other in the eyes, they laughed and they had started to communicate.
It has probably saved me. Coming soon….Sign In. Edit Inspector Montalbano —.
Commissario Salvo Montalbano 36 episodes, Peppino Mazzotta Dottor Pasquano 28 episodes, Luigi Caruso Caruso 20 episodes, Rosario Spata 17 episodes, Giovanni Guardiano Jacomuzzi 15 episodes, Aldo Messineo Enzo 13 episodes, Giacinto Ferro Questore Bonetti Alderighi 12 episodes, Raniela Ragonese Livia Burlando 10 episodes, Isabell Sollman Livia Burlando 8 episodes, Marco Cavallaro Tortorella 8 episodes, Carmela Gentile Beatrice Di Leo 8 episodes, Fabio Costanzo Pasquale 7 episodes, Ubaldo Lo Presti Enzo 6 episodes, Ketty Governali Ragonese 5 episodes, Pietro Biondi Questore Burlando 4 episodes, Biagio Pelligra Agente Gallo 4 episodes, Mirella Petralia Adelina 4 episodes, Pippo Provvidenti Arcangelo Prestifilippo 4 episodes, Giovanni Moschella Clementina Vasile Cozzo 3 episodes, Hamza Choukry Saverio Moscato 3 episodes, Gianluigi Fogacci Garrufo 3 episodes, Francesco Sineri Don Balduccio Sinagra 3 episodes, Gigliola Reina Pitrineddu's Mother 3 episodes, Biancamaria D'Amato Anna Tropeano 2 episodes, Dajana Roncione Leonard Attard 2 episodes, Ileana Rigano Costantino Morabito 2 episodes, Domenico Gennaro Ciccio Bellavia 2 episodes, Angelo Tosto Don Giummarra 2 episodes, Santo Pennisi Intelisano 2 episodes, Giovanni Argante Avvocato Emilio Laspina 2 episodes, Valbona Malay Katia 2 episodes, Antonino Bellomo Notaio Antuofermo 2 episodes, Fulvio D'Angelo Livia Burlando 2 episodes, Aglaia Mora Dottoressa Barresi 2 episodes, Ludovico Caldarera Concetta Prestia 2 episodes, Ermanno Amoroso 2 episodes, Ignazio Barcellona 2 episodes, Orazio Causarano Lopiparo 2 episodes, Giuseppe Schillaci Pasquano's wife 2 episodes, Maria Isabella Piana Esterina Trippodo 2 episodes, Aldo La Spina Avvocato Nino Barbera 2 episodes, Antonello PuglisiNecessary cookies are absolutely essential for the website to function properly.
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