This blog is all about the exploration of ADHD! We will investigate the causes, symptoms and conventional as well as unconventional treatments for ADHD.
This is the 3rd post in our series of discussions regarding ADHD and supplementation with the amino acid tyrosine. Some physicians and ADHD patients swear by it, but the results in the literature and clinical studies are often muddled. Why is this the case? Over the past few postings, I have been going over the metabolic pathway of how the body converts the amino acid tyrosine to our desired brain chemicals of dopamine and norepinephrine.
Imbalances of both dopamine and norepinephrine are typically seen in ADHD, and this imbalance is the target of most ADHD medications especially the stimulants during their modes of action. Here is the metabolic pathway on Tyrosine to Dopamine and Norephinephrine again you can click on the image to get a larger view, or see the original image source here : In our first post on ADHD and tyrosine supplementationwe went through the overview of this pathway.
In our last postingwe went through the first step of the process: the conversion of tyrosine also referred to as L-tyrosine to DOPA also referred to as L-DOPALevodopa and a number of trade names such as DoparLaradopar or Sinemetand the enzymes and nutrient co-factors involved in this conversion process.
I was going to start with the next step of the process today: the conversion of L-DOPA to dopamine, and the major enzymes involved. However, one of our readers from the previous posting on the conversion of Tyrosine to L-DOPA, posed an excellent question on a topic I failed to address which may be on the minds of several readers.
As a result, I will dedicate the remainder of this post to this question and save the next step of the tyrosine to dopamine pathway for the next blog entry. LynneC asked about the advantages of supplementing with tyrosine vs.
L-Tyrosine and Adderall: Be warned, Read Before Mixing!
As we saw in the previous posting on tyrosine supplementation for ADHDthe tyrosine to dopamine conversion requires one major enzyme tyrosine hydroxylase and several secondary enzymes to produce some of the compounds needed to help the tyrosine hydroxylase enzyme to function properlyas well as nutrient co-factors such as iron, zincmagnesiumand even antioxidants or reducing agents such as vitamin C.
Further complicating the issue, we saw that individual variation across the gene pool leads to different forms of this tyrosine hydroxylase enzyme, some of which are notably more effective or "potent" than others. In other words, some people are more disposed to having an efficient metabolic conversion of tyrosine to L-DOPA than others. If this is the case, why should we mess with tyrosine at all? Here are a few things to consider:.
Fascinating research, confirming my hypothesis that enzymatic functions are a major factor in ADHD. That said, the combination of tyrosine and P5P, personally, produces psychosis within 30 minutes. Phenylalanine, oddly, does not. The whole information that you provide is really useful and great and also the collection and facts are absolutely great to see!
Green Coffee Bean Extract. I do not know what to say but the word "nice" is enough. This study contradicts the statement at the beginning of this blog post that states that lower levels of dopamine are typical. In this study they found that there was not a lack of dopamine in adhd patients when compared with healthy patients. I think I need it. Are you out there 6 years later? When you're tired, you want to relax after a stressful working hours, you need to have time to take care of the kids active.
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Many studies proved that excess of L Tyrosine, more than Mg, won't benefit, as the body will discard it as excess. This article will help the internet people for setting up new weblog or even a weblog from start to end.
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Vyvanse and tyrosine
You have done really good work. Thank you for the information you provide, it helped me a lot.Hello and good evening. I've been on amphetamines for something like years now.
I used to be on Adderall XR and the dosage I had ranged from 20mgmg depending on the date. I've now been on Vyvanse for close to 6 months after taking a 6 month break from stimulants in general. My question here is this. Is this true? If so, does anyone know what dose I should take and when I should take the dose?
I was told at least 5 hours before taking Vyvanse Tyrosine at night, Vyvanse in the morning. Does this sound right to anyone? Apparently, this could be the cause of my perennial brain fog that wasn't even altered after being off of amphetamines for 6 months.
Thanks in advance for any help! But it will be more neurotoxic if if u introduce it. Sponsored Links. Originally Posted by dreams. I am a 21yo college student studying biochemistry and pre-medicine. I have extensive interest in pharmacology, particularly in the fields of mental disorders. I hope my advice is helpful but always discuss problems or changes to medications with your doctor first! Just because there drug addicts doesnt mean its wrong. Tyrosine is amazing.
I took it last night and this morning lowered my dose of Vyvanse from 50mg to 30mg and feel better then if I was taking the I can't really believe that one pill could make such a huge difference, but there we are. Also, I did notice that it helped a bit with the, "brain fog" I'd been experiencing as well. Whether or not this is strictly a placebo effect however, remains to be seen.L-tyrosine and Adderall are somewhat related.
L-tyrosine is a non-essential dietary amino acid and a precursor to dopamine and other catecholamines like norepinephrine. Certain combinations can have beneficial synergistic effects. For example, l-theanine synergizes with caffeine.
On the other hand, supplements can also dangerously interact with drugs. L-tyrosine is non-essential because it can be synthesized from phenylalanine in the body by the simple addition of an OH group. Adderall, by contrast, is a catecholamine-releasing agent. Adderall is a potent prescription drug that promotes dopamine release to increase attention and arousal.
Vyvanse, Theanine, Fish Oil, Tyrosine...for ADHD-PI. Help.
You might think that it could be dangerous to mix the two because both substances increase synaptic dopamine levels in the brain. Increasing dopamine via multiple mechanisms can be dangerous, but l-tyrosine only very weakly and indirectly increases dopamine. This works better because dopamine and other catecholamines norepinephrine will be depleted after Adderall use during the day.
Once l-tyrosine penetrates the blood-brain barrier, it is converted to L-DOPA by the enzyme tyrosine hydroxylase. In the synthesis of Dopamine, Tyrosine hydroxylase is the rate-limiting step, so tyrosine hydroxylase activity is actually the bottleneck that controls the rate dopamine is synthesized. In summary, tyrosine is converted to DOPA, which is converted to dopamine, which is converted to norepinephrine.
Both dopamine and norepinephrine are biologically neurotransmitters. L-DOPA is actually not available as a supplement. By taking l-tyrosine is a milder and non-toxic method to boost dopamine. Amphetamine neurotoxicity is well-documented. There are a few things you can do to hedge your bets and mitigate the risk of neurotoxicity. The following have been noted to protect against amphetamine-induced neurotoxicity. The consensus is that psychostimulants like Adderall diminish testosterone.
Adderall is comprised of mixed amphetamine salts and is used in the treatment of ADHD and narcolepsy. This effect may be related to appetite suppression or sleep disruption. Psychostimulants like Adderall can cause insomnia and impair sleep quality. Testosterone is an endogenous anabolic steroid and sex hormone secreted by the male testes and to a lesser extent the adrenal glands. How does Adderall treatment affect testosterone secretion?I absolutely have to comment on this post.
Everything you described in this post describes me and my vyvanse withdrawls. A little bit of history in regards to adhd for myself. My mother put me on Ritalin in the fourth grade, switched to Concerta in high school which I started flushing down the toilet. I did not like the way Concerta made me feel around my friends in high school, so I refused to take it.
I great grades when I was on it, but also had a temper like no other so I stopped without telling my mother. Eventually, the last two years of high school, she knew I wasn't on it. I made average grades and graduated just fine.
However, into college I started partying and finding excuses to easily distract me from studying. It has done amazing things as far as productivity, focus, and school are concerned. I now have a degree in Radiologic Technology and have just recently started a specilization program in the radiology field into Radiation Therapy.
All of a sudden, I would rather be at school than at work because I believe that I have found the career of my dreams! The medicine has worked great once again with my focus. However, I have recently been battling with my Vyvanse because I literally burnt myself out during x-ray school because of trying to be "superwomen" while on the medicine.
I did have the summer off after passing my boards, although I basically slept because I decided I don't want to be on this medicine my whole life and thought my body could use a break. I am just curious because when I took the break, I was so so unproductive which was okay because I had been nonstop buring myself out for the last two years. My plan is to get off of it completely again after passing my Radiation Therapy boards. Except, I am so afraid of not being productive when I am finally done with school and want to sleep all the time, when I should be ready to take that next step in life.
My question to you is this: Did you come out of your slump after taking Vyvanse? If so, what worked for you or did you try supplements for increasing your dopamine naturally? Has anything you tried helped with the focus and concentration factor. Sorry for the lengthy time before I replied. To answer your questions: I did come out of my slump after taking Vyvanse. I decided to buy Bentonite Clay to detox my system. It's no fun,so make sure you have a few weeks of relaxation to detox.
Doing yoga and drinking a lot of water helps with the detox. You don't want to take anything except vitamins and minerals while detoxing. After a few weeks, I started taking L-Theanine to help with concentration and focus. It's not as potent and Vyvanse, but it does the job. Also, avoid caffeine all together, and start drinking more water and drinks that hydrate the body. Caffeine is a terrible for healthy hormone levels. I am currently taking Ashwagandha supplements to help me feel calm and focused.
So far, it's worked the best of all the supplements that I've tried thus far. I hope this information helps! Thank you for the BLOG!! Many are addicted to adrenaline rushes excitement and do not realize it. Cravings are indicators of issues in diet so are mood swings, anger, and skin problems.This paper documents a retrospective pilot study of a novel approach for treating attention deficit hyperactivity disorder ADHD with amino acid precursors of serotonin and dopamine in conjunction with urinary monoamine assays subjected to organic cation transporter OCT functional status determination.
The goal of this research was to document the findings and related considerations of a retrospective chart review study designed to identify issues and areas of concern that will define parameters for a prospective controlled study.
This study included 85 patients, aged 4—18 years, who were treated with a novel amino acid precursor protocol. Their clinical course during the first 8—10 weeks of treatment was analyzed retrospectively.
The study team consisted of PhD clinical psychologists, individuals compiling clinical data from records, and a statistician. The patients had been treated with a predefined protocol for administering amino acid precursors of serotonin and dopamine, along with OCT assay interpretation as indicated. In patients who achieved no significant relief of symptoms with only amino acid precursors, OCT assay interpretation was utilized.
In this subgroup, The efficacy of this novel protocol appears superior to some ADHD prescription drugs, and therefore indicates a need for further studies to verify this observation.
The findings of this study justify initiation of further prospective controlled studies in order to evaluate more formally the observed benefits of this novel approach in the treatment of ADHD. The diagnosis of ADHD is dependent upon meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition DSM-IV criteria in the areas of inattention, hyperactivity, and impulsivity which negatively affect performance in school and work, as well as in relationships with others.
In response, the pharmaceutical industry has demonstrated, to the satisfaction of the US Food and Drug Administration FDAthat certain drugs that impact the monoamine systems meet FDA efficacy standards. Examples of these drugs include neutral sulfate salts of dextroamphetamine and amphetamine, 9 methylphenidate, 10 dexmethylphenidate, 11 atomextine, 12 and lisdexamfetamine dimesylate. Side effects and adverse reactions associated with ADHD prescription medications are significant, serious, and potentially life-threatening.
The following is a limited list of these events associated with the ADHD group of drugs as a whole, which include, but are not limited to: 9 — Sudden death in cases with pre-existing structural cardiac abnormalities or other serious heart problems. Exacerbation of symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder. Treatment by stimulants at usual doses can cause emergent psychotic or manic symptoms, eg, hallucinations, delusional thinking, or mania in children and adolescents without prior history of psychotic illness or mania.
Amphetamines may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or vehicles. Higher incidence of infection, photosensitivity reaction, constipation, tooth disorders, emotional liability, decreased libido, somnolence, speech disorder, palpitation, twitching, dyspnea, sweating, dysmenorrhea, and impotence.
Integument disorders including, but not limited to, urticaria, rash, and hypersensitivity reactions, including angioedema and anaphylaxis; serious skin rashes, including Stevens Johnson syndrome and toxic epidermal necrolysis. Contraindicated in patients with marked anxiety, tension, and agitation, because the drugs may aggravate these symptoms. These drugs do not increase the total number of neurotransmitter molecules in the central nervous system. Their primary mechanism of action is thought to be reuptake inhibition which sets up conditions that move neurotransmitters from one place to another.
There has been no previous peer-reviewed literature published addressing the efficacy of amino acid precursors of serotonin and dopamine simultaneously administered in the treatment of ADHD.
The immediate amino acid precursors of serotonin and dopamine are 5-hydroxytryptophan 5-HTP and L-3,4-dihydroxyphenylalanine L-doparespectively.
They freely cross the blood-brain barrier and are then synthesized into serotonin and dopamine without biochemical feedback inhibition. L-tryptophan and L-tyrosine have the ability to be synthesized into serotonin and dopamine, respectively. They are actively transported across the blood—brain barrier in competition with other amino acids.Pros/Cons of L-Tyrosine
Synthesis of serotonin and dopamine from L-tryptophan and L-tyrosine, respectively, is regulated by biochemical feedback.Remember me This is not recommended for shared computers. Sign in anonymously Don't add me to the active users list. Posted 10 September - AM. Posted 10 September - PM. Posted 11 September - PM. Posted 16 September - AM. Posted 05 November - AM. Posted 10 November - PM. Posted 23 November - PM. I've been lurking on the forums for quite some time and I finally decided to actually get involved.
Hopefully, this knowledgable community will be able to help me out. Prior to that I struggled all through high school and also had issues in college. I have the classic symptoms and cognitive problems most people with ADHD-PI have, with no comorbidities depression, schizophrenia, etc.
I recently started doing research into supplementation with nootropics and decided to start out with a few. I should mention that I'm 23, male, lbs and I just started a new University program in Neuroscience which is very demanding and the primary purpose for supplementation. I know my stack and the organization may seem strange, but I'm just starting out.
Please recommend any re-arrangements, additions, modifications, advice or anything at all. Thank you all in advance. Cheers, Kosta. I just found this thread again by happenstance when Googling some drug combos so apologies for the delayed response. I have cycled a few experiments with Piracetam, high dose fish oil, and deprenyl and it turned out to be kind of a mixed bag.
I am actually trying it again now and what I'm finding to be consistent with my trials is that although my cognition seems enhanced, my mood lacks continuity. I sometimes feel like I "go inside myself" and become easily agitated. It's challenging to put any of this in definite terms because some days are different than others. I may be adding l-thenanine, picamilon or PEA be careful to the lineup so see if I can address the mood issues. Posted 24 November - AM. Posted 24 November - PM.
But all the supplements you are taking seem to be built around the Vyvanse multivitamin for all around health, theanine to reduce the negative effects of the vyvanse, the tyrosine to rebuild the dopamine so that seems pretty good.
Only thing I would add would be whey protein for meal replacements when you don't feel like eating or are on the go. What dose of Vyvanse are you on?L-Tyrosine is an amino acid that aids in producing 3 essential neurotransmitters: norepinephrine, serotonin, and dopamine, which are responsible for important functions like mood, memory, muscle coordination and appetite.
Dopamine also is vital in focus and concentration and is enhanced in individuals taking stimulants. Tyrosine also is helpful in relieving stress, building adrenaline stores, improving mood and in improving mental acuity. Airplane pilots have been reported taking Tyrosine to increase their focus during long flights. Dopamine is produced from the amino acid tyrosine with the help of iron, vitamin C, folate, vitamin B6 and tetrahydrobiopterin.
Low dopamine levels impair attention and focus. Some parents of Autistic kids report improvement in speech and fewer sensory issues when supplementing with Tyrosine. As dopamine controls the flow of information to the other parts of the brain which occurs in the frontal lobes called the prefrontal cortexit is not surprising that taking a supplement that increasing dopamine may be be beneficial in mood regulation often problematic in Autism.
It is important to ensure you get a daily proper diet that promotes a good environment for optimal brain functioning.
Dopmaine levels can be enhanced by taking B vitamin and amino acids. Supplementing with key essential B vitamins B6, Folate and B12 with amino acids acetyl l-carnitine, L-tyrosine and choline has shown some promise in improving executive functioningmood regulationinformation processing and emotional responses all which affect Autistic patients limiting their socialization and frustration tolerance of the individual as well as those around them.
Germaine B. Hawkins, D.